World Diabetes & Endocrinology Conference
World Diabetes & Endocrinology Conference
University of California School of Medicine
USA
Dr Levin is a Clinician-Scientist and
Distinguished Professor of Medicine and Biochemistry at the University of
California School of Medicine in the USA. Dr Levin is Vice-Chairman of the
Department of Medicine and Chief, Endocrinology, Diabetes, and Metabolism at
UC-Irvine and the Long Beach VA Medical Center.
He is an elected member of the Association
of American Physicians, and is a current Associate Editor of the Journal, Endocrinology,
for a 4th year. Dr Levin has been a keynote or plenary speaker at
numerous meetings including the Endocrine Society Annual Meeting, Israeli
Annual Endocrine Society Meeting, FASEB, and Keystone Conferences. He was
awarded the 2013 Solomon Berson Distinguished Lecture Award by the American
Physiological Society.
Dr Levin’s research focus since 1996 has
been on extra-nuclear estrogen receptors in the vasculature and heart, breast
cancer, and stem cell maturation. He defined that all sex steroid receptors
(estrogen, progesterone, and androgen classic receptors) are palmitoylated and
the sites were defined and found to be necessary for translocation to the
plasma membrane. There these receptors respond to the sex steroid ligand with
activation of multiple signaling pathways as G-protein coupled receptors. His
lab has more recently defined the importance of the membrane receptor as being
required and sometimes sufficient to regulate cell function and key gene
expression. However for most gene regulation by the nuclear receptor, signaling
by membrane ER is required for the ability of the nuclear ER pool to alter gene
expression and subsequent development of function of the cell.