World Geriatrics & Aging Congress
World Geriatrics & Aging Congress
LSU Health New Orleans
United States
Nicolas G. Bazan, M.D., Ph.D., has been called “a true
renaissance man”: research scientist, teacher, mentor, community leader,
author, screenplay co-writer/executive movie producer, patron of the arts, and
entrepreneur. Born in Los Sarmientos, Tucuman, Argentina, Dr. Nicolas Bazan's
defining moment was witnessing an aunt suffer a seizure while walking him to a
piano lesson when he was a young boy, putting him on the path to becoming a
medical doctor and one of the world's premier neuroscientists.
In his first laboratory at the Clarke Institute of Psychiatry in Toronto, Canada, Dr. Bazan discovered that brain ischemia (like in stroke), seizures (like in epilepsy) or electroconvulsive shock (a therapy for depression) trigger the rapid release of unesterified essential fatty acids (docosahexaenoic and arachidonic acids) from membranes through phospholipase A2. Soon after, his lab extended these seminal observations to the retina, vision and retinal degenerative diseases. These findings became a citation classic ("Neural Stimulation or Onset of Cerebral Ischemia Activates Phospholipase A2", Bazan NG, Current Contents/Life Sciences, 30:10, 1991). Based upon this early work, he then discovered that release of the mediator, platelet-activating factor (PAF), is a major signaling event of inflammatory responses in the eye and brain, and he identified PAF binding sites in synaptic and intracellular membranes.
Currently, he is beginning to apply his discoveries (patents exclusively licensed from the University in two startup companies that he co-founded). They are NeuResto Therapeutics, LLC (novel discoveries for Alzheimer's, Parkinson's, retinal degenerations, stroke, traumatic brain injury, and other brain and retina diseases; www.neuresto.com) and South Rampart Pharma, LLC (novel non-addictive, non-toxic painkiller; southrampartpharma.com)