Paolina Crocco has her expertise in research the impact of genetic variability on several human complex traits, including normal and pathological aging as well as longevity. She has explored various analytical approaches, from case-control studies using the candidate gene approach, to linkage disequilibrium analysis in regions involved in human longevity, up to the integration of demographic data to genetics. Currently her studies are dedicated to the analysis of large datasets of SNPs through network approaches, to the pathway-based analysis of SNPs sets related to human aging and age-related diseases, as well as to the study of the contribution of non-genetic factors, including nutrition, in the predisposition to a successful aging. In addition to genetic factors, epigenetic events are emerging as important factors in aging and longevity. In this context, she is investigating the role of specific circulating microRNAs in the development of frailty in the elderly